N-甲基-1-苯基-7,8-二甲氧基-2,3,4,5-四氢-3-苯并氮杂卓合成路线 （共 14 条）
反应条件
1: 53 percent / Et3N / diethyl ether / 0.5 h / 0 °C
2: 70 percent / NaIO4 / H2O; methanol / 15 h / Ambient temperature
3: 70 percent / TFAA / CH2Cl2 / 20 h / Ambient temperature
4: 47 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
5: 39 percent / Raney Ni / ethanol / 4 h / Heating
View Scheme
参考文献
Ishibashi; Harada; Okada; Somekawa; Kido; Ikeda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 4 p. 939 - 943
反应条件
1: 47 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature
2: 39 percent / Raney Ni / ethanol / 4 h / Heating
View Scheme
参考文献
Ishibashi; Harada; Okada; Somekawa; Kido; Ikeda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 4 p. 939 - 943
反应条件
HBF4*(CH3)2O in dichloromethane
T=-20°C; 69 h; Product distribution;
参考文献
Coote, Steven J.; Davies, Stephen G.; Middlemiss, David; Naylor, Alan
Tetrahedron: Asymmetry, 1990 , vol. 1, # 1 p. 33 - 56
反应条件
2: 86 percent / BBr3 / CH2Cl2 / 1 h / -15 - 25 °C
View Scheme
参考文献
Kaiser; Dandridge; Garvey; Hahn; Sarau; Setler; Bass; Clardy
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 697 - 703
