1,3-二氢-1-（1,2,3,6-四氢-4-吡啶基）-2氢苯咪唑-2-酮合成路线 （共 10 条）
反应条件
N-bromosuccinmide; triphenylphosphine in tetrahydrofuran T=0°C; 2 h;
参考文献
Ohno, Michihiro; Miyamoto, Mitsuko; Hoshi, Kazuhiro; Takeda, Takahiro; Yamada, Naohiro; Ohtake, Atsushi
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5279 - 5294
反应条件
1: LiAlH4 / tetrahydrofuran / 1.) reflux, 2 h, 2.) RT, overnight 2: 70 percent / 48percent HBr, acetic acid / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 27, # 6 p. 571 - 579
反应条件
1: tetrahydrofuran / Heating 2: H2 / 10 percent Pd/C / tetrahydrofuran / 2068.59 Torr 3: LiAlH4 / tetrahydrofuran / 3 h / Heating 4: 88 percent / CBr4; Ph3P / CH2Cl2 / 24 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3549 - 3557
反应条件
1: H2 / 10 percent Pd/C / tetrahydrofuran / 2068.59 Torr 2: LiAlH4 / tetrahydrofuran / 3 h / Heating 3: 88 percent / CBr4; Ph3P / CH2Cl2 / 24 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3549 - 3557
反应条件
1: LiAlH4 / tetrahydrofuran / 3 h / Heating 2: 88 percent / CBr4; Ph3P / CH2Cl2 / 24 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 16 p. 3549 - 3557
反应条件
indium(III) chloride; dimethylmono-chlorosilane T=25°C; 15 h;
参考文献
Miyai, Takashi; Onishi, Yoshiyuki; Baba, Akio
Tetrahedron, 1999 , vol. 55, # 4 p. 1017 - 1026
反应条件
1: Na, EtOH 2: aq. HBr View Scheme
参考文献
Pharmaceutical Chemistry Journal, , p. 198 - 200
Khimiko-Farmatsevticheskii Zhurnal, , # 4 p. 25 - 27
反应条件
1: carbon dioxide With N(Et)4ClO4 in acetonitrile T=0°C; Electrochemical reaction; 2: 3,3-diphenyl-1-propyl bromide in acetonitrile
参考文献
Mucciante, Vittoria; Rossi, Leucio; Feroci, Marta; Sotgiu, Giovanni
Synthetic Communications, 2002 , vol. 32, # 8 p. 1205 - 1210
反应条件
lithium in diethyl ether T=-40°C;
参考文献
Maercker, Adalbert; Passlack, Michael
Chemische Berichte, 1983 , vol. 116, # 2 p. 710 - 723
反应条件
lithium in tetrahydrofuran
Product distributionMechanism;
参考文献
Maercker, Adalbert; Passlack, Michael
Chemische Berichte, 1983 , vol. 116, # 2 p. 710 - 723
