diisobutylaluminium hydride in toluene T=-78°C; 0.666667 h; Inert atmosphere;

caesium carbonate in N,N-dimethyl-formamide T=25°C; 4 h; Inert atmosphereSchlenk technique;

2,2''-bis[1-(dialkylphosphino)ethyl]1,1''-biferrocene; hydrogen; bis(norbornadiene)rhodium(I) hexafluorophosphate in 1,2-dichloro-ethane T=50°C; Hydrogenation; P=735.508 Torr; 24 h;

1: 1-(tert-butoxy-carbonyl)piperidine With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether; cyclohexane T=-78°C; 3 h; Inert atmosphere; 2: With C12H24N2O(2-)*2Li(1+) in diethyl ether; cyclohexane T=-45°C; 3 h; Inert atmosphere; 3: methyl chloroformate in diethyl ether; cyclohexane T=-78°C; 2 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

hydrogen; palladium on activated charcoal in ethanol atmospheric pressure;

1: 1-(tert-butoxy-carbonyl)piperidine With sec.-butyllithium; (+)-sparteine surrogate in hexanes; diethyl ether T=-78 - -20°C; Inert atmosphere; 2: methyl chloroformate in hexanes; diethyl ether T=-78 - 20°C; Inert atmosphere; optical yield given as percent ee;

1: 77 percent / Mn(OAc)2*4H2O; peracetic acid; NaOAc / acetic acid / 4 h / 22 °C 2: 79 percent / AcOH 3: H2 / 5percent Pd/C View Scheme

1: N-Boc-2-(tributylstannyl)piperidine With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; Inert atmosphere; 2: methyl chloroformate in tetrahydrofuran; hexanes T=-78 - 20°C; Inert atmosphere; optical yield given as percent ee;

hydrogen; 5percent Pd/C

1: 1-(tert-butoxy-carbonyl)piperidine With sec.-butyllithium; (+)-sparteine surrogate in hexanes; diethyl ether T=-78°C; 6 h; Inert atmosphere; 2: dimethyl(phenyl)silyl chloride in hexanes; diethyl ether T=-78 - 40°C; Inert atmosphere; 3: methyl chloroformate in hexanes; diethyl ether T=-40 - 20°C; Inert atmosphere; optical yield given as percent ee;