(2R,4R)-4-甲氧基-1,2-吡咯烷二羧酸-1-(1,1-二甲基乙基)-2-甲酯合成路线 （共 3 条）
反应条件
silver(l) oxide in acetone T=20°C; 48 h;
参考文献
MERCK PATENT GMBH
Patent: WO2004/87646 A2, 2004 ;
Location in patent: Page/Page column 75-76 ;
WO 2004/087646 A2
反应条件
thionyl chloride; NaH; triethylamine in tetrahydrofuran; methanol; dichloromethane; water
参考文献
C and C Research Laboratories
Patent: US6201006 B1, 2001 ;
反应条件
1: With lithium hydroxide in tetrahydrofuran; water T=20°C; 5 h; 2: With hydrogenchloride in tetrahydrofuran; 1,4-dioxane; water
参考文献
ASTRAZENECA AB; ASTRAZENEKA UK LIMITED
Patent: WO2005/26156 A1, 2005 ;
Location in patent: Page/Page column 103 ;
WO 2005/026156 A1
