3-氧代-3,4-二氢-2H-苯并[1,4]噁嗪-7-甲醛合成路线 （共 6 条）
反应条件
tin(ll) chloride in ethanol
T=70°C; 0.5 h;
参考文献
UNIVERSITY OF LJUBLJANA; LEK PHARMACEUTICALS d.d.
Patent: WO2005/51934 A1, 2005 ;
Location in patent: Page/Page column 37-38 ;
反应条件
manganese(IV) oxide in tetrahydrofuran; dichloromethane
1.5 h;
参考文献
Morphochem Aktiengesellschaft Fur Kombinatorische Chemie
Patent: US2010/324030 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 92 percent / KF / dimethylformamide / 24 h / 60 °C
2: 64 percent / SnCl2*2H2O / ethanol / 0.5 h / 70 °C
View Scheme
参考文献
Anderluh, Petra Stefanic; Anderluh, Marko; Ilas, Janez; Mravljak, Janez; Dolenc, Marija Sollner; Stegnar, Mojca; Kikelj, Danijel
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3110 - 3113
反应条件
potassium carbonate in acetonitrile
T=20°C; Cyclization;
参考文献
Belliotti, Thomas R.; Wustrow, David J.; Brink, Wouter A.; Zoski, Kim T.; Shih, Yu-Hsin; Whetzel, Steven Z.; Georgic, Lynn M.; Corbin, Ann E.; Akunne, Hyacinth C.; Heffner, Thomas G.; Pugsley, Thomas A.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5181 - 5187
反应条件
1: H2 / Raney-Ni / tetrahydrofuran
2: NaHCO3 / tetrahydrofuran / 1.5 h / 20 °C
3: aq. HCl / methanol / 20 °C / pH 1
4: K2CO3 / acetonitrile / 20 °C
View Scheme
参考文献
Belliotti, Thomas R.; Wustrow, David J.; Brink, Wouter A.; Zoski, Kim T.; Shih, Yu-Hsin; Whetzel, Steven Z.; Georgic, Lynn M.; Corbin, Ann E.; Akunne, Hyacinth C.; Heffner, Thomas G.; Pugsley, Thomas A.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5181 - 5187
反应条件
1: aq. HCl / methanol / 20 °C / pH 1
2: K2CO3 / acetonitrile / 20 °C
View Scheme
参考文献
Belliotti, Thomas R.; Wustrow, David J.; Brink, Wouter A.; Zoski, Kim T.; Shih, Yu-Hsin; Whetzel, Steven Z.; Georgic, Lynn M.; Corbin, Ann E.; Akunne, Hyacinth C.; Heffner, Thomas G.; Pugsley, Thomas A.; Wise, Lawrence D.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 25 p. 5181 - 5187
