2-氨基-5-苯基-1,3,4-噻二唑合成路线 （共 74 条）
反应条件
1: (i) NaNO2, aq. HCl, (ii) (heating) 2: N2H4*H2O / ethanol 3: Py View Scheme
参考文献
Potts,K.T.; Huseby,R.M.
Journal of Organic Chemistry, 1966 , vol. 31, p. 3528 - 3531
反应条件
N-ethyl-N,N-diisopropylamine in toluene T=120°C; 16 h; Sealed tube;
参考文献
Mammoliti, Oscar; Quinton, Evelyne M.; Loones, Kristof T.J.; Nguyen, Anh Tho; Wouters, Johan; Van Lommen, Guy
Tetrahedron, 2013 , vol. 69, # 5 p. 1669 - 1680
反应条件
1: 85 percent / NaNO2; aq. HCl; Cu / -5 - 65 °C 2: 96 percent / aq. NH2NH2 / ethanol / 0.5 h / Heating View Scheme
参考文献
Flowers, William T.; Robinson, John F.; Taylor, David R.; Tipping, Anthony E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 349 - 355
反应条件
aluminium trichloride T=180°C; 5 h;
参考文献
Prasad, V S R; Reddy, K Kondal
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 4 p. 435 - 436
反应条件
PPA T=150 - 160°C; 3 h;
参考文献
Santagati, Andrea; Santagati, Maria; Russo, Fillippo; Ronsivalle, Giuseppe
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 949 - 953
反应条件
hydrogenchloride; copper; sodium nitrite
T=-5 - 65°C;
参考文献
Shen, Hong C.; Ding, Fa-Xiang; Colletti, Steven L.
Organic Letters, 2006 , vol. 8, # 7 p. 1447 - 1450
反应条件
1: 94 percent / iPentONO2; CuBr2 / acetonitrile / 2 h / 20 °C
2: 91 percent / aq. Na2CO3 / Pd(PPh3)4 / dimethylformamide / 3 h / 85 °C
View Scheme
参考文献
Vachal, Petr; Toth, Leslie M.
Tetrahedron Letters, 2004 , vol. 45, # 38 p. 7157 - 7161
反应条件
Ammonium thiocyanate
1.) acetone, heated water-bath, 1 h, 2.) reflux, 3 h; Yield given. Multistep reaction;
参考文献
Sridevi, G.; Rao, P. Jayaprasad; Reddy, K. Kondal
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 997 - 1000
参考文献
Elnagdi,M.H. et al.
Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 61 - 64
参考文献
Maffii et al.
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 187,196
