2-氨基-5-苯基-1,3,4-噻二唑合成路线 （共 74 条）
反应条件
1: NaNO2; aq. HCl / Cu
2: 78 percent / thiourea / ethanol / Heating
3: 75 percent / NaOH / ethanol; H2O
4: 68 percent / H2O2 / acetic acid
View Scheme
参考文献
Foroumadi; Tabatabai; Gitinezhad; Zarrindast; Shafiee
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 1 p. 31 - 33
反应条件
1: (i) NaNO2, aq. HCl, (ii) (heating)
2: N2H4*H2O / ethanol
3: Py
4: POCl3 / xylene
View Scheme
参考文献
Potts,K.T.; Huseby,R.M.
Journal of Organic Chemistry, 1966 , vol. 31, p. 3528 - 3531
反应条件
copper(ll) bromide; isopentyl nitrite in acetonitrile
T=20°C; 2 h;
参考文献
Vachal, Petr; Toth, Leslie M.
Tetrahedron Letters, 2004 , vol. 45, # 38 p. 7157 - 7161
反应条件
in N,N-dimethyl-formamide
T=90°C; 1 h;
参考文献
Rosenthal, Andrew S.; Dexheimer, Thomas S.; Gileadi, Opher; Nguyen, Giang H.; Chu, Wai Kit; Hickson, Ian D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5660 - 5666
