2-氯-5'-氟-2'-羟基-苯乙酮合成路线 (共 3 条)
反应条件
1: With AlCl3, aluminium chloride in dichloromethane T=20 - 38°C; Friedel-Crafts reaction; 72 h; Heating / reflux; 2: With water T=0°C; 0.666667 h;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: WO2004/41805 A1, 2004 ;
Location in patent: Page 42 ;
反应条件
1: 2: With aluminium trichloride T=140°C; Further stages.;
参考文献
Journal of the American Chemical Society, , vol. 129, # 26 p. 8328 - 8332
反应条件
sodium acetate in methanol
参考文献
Kozikowski, Alan P.; Gaisina, Irina N.; Yuan, Hongbin; Petukhov, Pavel A.; Blond, Sylvie Y.; Fedolak, Allison; Caldarone, Barbara; McGonigle, Paul
Journal of the American Chemical Society, 2007 , vol. 129, # 26 p. 8328 - 8332