3''-氨基-4''-氟苯乙酮合成路线 （共 5 条）
反应条件
hydrogen; Ra-Ni in methanol T=20 - 37°C; 1.5 h;
参考文献
Protiva, Miroslav; Jilek, Jiri; Rajsner, Miroslav; Sindelar, Karel; Bartl, Vaclav; et al.
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 7 p. 1811 - 1833
反应条件
1: 79 percent / conc. H2SO4; HNO3 / -15 °C 2: 80 percent / H2 / Pt(S)/C / ethanol / 2585.74 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 10 p. 1725 - 1728
反应条件
sodium hydroxide; hydrazine; 1,2-bis-(2-hydroxyethoxy)-ethane T=180°C;
参考文献
Oelschlaeger,H.; Schreiber,O.
Justus Liebigs Annalen der Chemie, 1961 , vol. 641, p. 81 - 94
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0 - 5°C;
2: With copper(I) oxide; sulfuric acid; water; copper(II) nitrate
T=20°C; 0.25 h;
参考文献
AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/103260 A1, 2007 ;
Location in patent: Page/Page column 64 ;
WO 2007/103260 A1
