3-(4-叔丁基苯基)-3-氧丙酸甲酯合成路线 (共 2 条)
反应条件
sodium hydride in tetrahydrofuran T=65°C; 3 h;
参考文献
KALYPSYS, INC.
Patent: US2009/62253 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090062253 A1
反应条件
1: With sodium hydrogencarbonate; triphenylphosphine; bis(η3-allyl-μ-chloropalladium(II)) in N,N-dimethyl-formamide T=150°C; Heck reaction; 20 h; 2: With hydrogenchloride in dichloromethane; water T=25°C;
参考文献
Battace, Ahmed; Feuerstein, Marie; Lemhadri, Mhamed; Zair, Touriya; Doucet, Henri; Santelli, Maurice
European Journal of Organic Chemistry, 2007 , # 19 p. 3122 - 3132