2-溴-1-(3-(三氟甲基)苯基)乙酮合成路线 （共 14 条）
反应条件
bromine in diethyl ether 3 h; Ambient temperature;
参考文献
Sanfilippo; Urbanski; Beers; Eckardt; Falotico; Ginsberg; Offord; Press; Tighe; Tomko; Andrade-Gordon
Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 34 - 41
反应条件
bromine in dichloromethane T=20°C; 4 h; Inert atmosphereLarge scale reaction;
参考文献
May, Scott A.; Johnson, Martin D.; Braden, Timothy M.; Calvin, Joel R.; Haeberle, Brian D.; Jines, Amy R.; Miller, Richard D.; Plocharczyk, Edward F.; Rener, Gregory A.; Richey, Rachel N.; Schmid, Christopher R.; Vaid, Radhe K.; Yu, Hannah
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 982 - 1002
反应条件
in xylene T=60°C; Ea; Thermodynamic data;
参考文献
Journal of Organic Chemistry, , vol. 52, # 14 p. 3143 - 3150
参考文献
Saggiomo; Kano; Kikuchi; Okubo; Shinbo
Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 989 - 994
反应条件
in ethanol 0.5 h; Heating; Yield given;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 43, # 9 p. 1497 - 1504
反应条件
in ethanol; water T=20°C; Nitrylation; 2 h;
参考文献
Baraldi, Pier Giovanni; Zaid, Abdel Naser; Lampronti, Ilaria; Fruttarolo, Francesca; Pavani, Maria Giovanna; Tabrizi, Mojgan Aghazadhe; Shryock, John C.; Leung, Edward; Romagnoli, Romeo
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 1953 - 1957
反应条件
0.5 h; temp. below 30 deg C;
参考文献
Meyer, Donald, R.; Weintraub, Philip M.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 451 - 453
反应条件
1: 24.3 percent / 0.5 h / temp. below 30 deg C
2: 35.9 percent / pyridine / 18 h / Ambient temperature
View Scheme
参考文献
Meyer, Donald, R.; Weintraub, Philip M.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 451 - 453
反应条件
1: ethanol / |Reflux
2: sodium hydroxide; water / ethanol / 20 °C
View Scheme
参考文献
Nitta, Aiko; Fujii, Hideaki; Sakami, Satoshi; Satoh, Mikiya; Nakaki, Junko; Satoh, Shiho; Kumagai, Hiroki; Kawai, Hideki
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7036 - 7040
反应条件
1: ethanol / |Reflux
2: sodium hydroxide; water / ethanol / 20 °C
3: hydrogenchloride / 1,4-dioxane; water / |Reflux
View Scheme
参考文献
Nitta, Aiko; Fujii, Hideaki; Sakami, Satoshi; Satoh, Mikiya; Nakaki, Junko; Satoh, Shiho; Kumagai, Hiroki; Kawai, Hideki
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7036 - 7040
