2-溴-1-(3-(三氟甲基)苯基)乙酮合成路线 (共 14 条)
反应条件
(i), (ii) H2O; Multistep reaction;
参考文献
American Hoechst Corporation
Patent: US3997557 A1, 1976 ;
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in tetrachloromethane
T=20°C;
2: With hydrogenchloride; ethanol; water
T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/140947 A1, 2008 ;
Location in patent: Page/Page column 16 ;
WO 2008/140947 A1
反应条件
sodium azide in tetrahydrofuran; water
T=20°C; Inert atmosphereLarge scale reaction;
参考文献
May, Scott A.; Johnson, Martin D.; Braden, Timothy M.; Calvin, Joel R.; Haeberle, Brian D.; Jines, Amy R.; Miller, Richard D.; Plocharczyk, Edward F.; Rener, Gregory A.; Richey, Rachel N.; Schmid, Christopher R.; Vaid, Radhe K.; Yu, Hannah
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 982 - 1002
反应条件
in N-methyl-acetamide; water
参考文献
American Hoechst Corporation
Patent: US3997557 A1, 1976 ;