5,10-二氢-5-甲基吩嗪合成路线 （共 17 条）
反应条件
hydrogen bromide; dimethyl sulfoxide T=100 - 110°C; oxidative demethylation; 2 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 36, # 4 p. 1057 - 1064
反应条件
1: 17 percent / HBr; DMSO / 2 h / 100 - 110 °C 2: 7 percent / HBr; DMSO / H2O / 2 h / 80 - 90 °C View Scheme
参考文献
Sugimoto, Akira; Yoshino, Yasuyuki; Watanabe, Ryo; Mizuno, Kazuhiko; Uehara, Kaku
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 4 p. 1057 - 1064
反应条件
1: fully reduced 5-methylphenazinium With n-butyllithium in ethylene glycol dimethyl ether; hexane Metallation; 2: 4-(2-bromoethyl)nitrobenzene in ethylene glycol dimethyl ether T=20°C; Condensation; 3 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 36, # 4 p. 849 - 856
反应条件
1: 73 percent / HBr; DMSO / 2 h / 100 - 110 °C 2: 75 percent / nitrobenzene / 0.12 h / 100 °C View Scheme
参考文献
Sugimoto, Akira; Yoshino, Yasuyuki; Watanabe, Ryo; Mizuno, Kazuhiko; Uehara, Kaku
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 4 p. 1057 - 1064
反应条件
n-butyllithium in ethylene glycol dimethyl ether; hexane 2 h; Ambient temperature; Yield given;
参考文献
Sugimoto, Akira; Kotani, Takeshi; Tsujimoto, Junko; Yoneda, Shigeo
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 435 - 438
反应条件
1: in nitrobenzene
T=100°C; Methylation; 0.116667 h;
2: With sodium dithionite in ethanol
Reduction;
参考文献
Sugimoto, Akira; Matsumoto, Keisuke; Maruyama, Hideyuki; Mizuno, Kazuhiko; Uehara, Kaku
Journal of Chemical Research, Miniprint, 1999 , # 2 p. 601 - 727
反应条件
sodium dithionite in ethanol
Reduction;
参考文献
Sugimoto, Akira; Yoshino, Yasuyuki; Watanabe, Ryo; Mizuno, Kazuhiko; Uehara, Kaku
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 4 p. 1057 - 1064
反应条件
ascorbic acid powder
参考文献
Richter, Helen W.; Waddell, Walter H.
Journal of the American Chemical Society, 1982 , vol. 104, # 17 p. 4630 - 4634
反应条件
1: sodium dithionite / ethanol; H2O / Heating
2: butyl-lithium / 1,2-dimethoxy-ethane; hexane / 0.5 h / Ambient temperature
View Scheme
参考文献
Sugimoto, Akira; Kotani, Takeshi; Tsujimoto, Junko; Yoneda, Shigeo
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 435 - 438
反应条件
n-butyllithium in ethylene glycol dimethyl ether; hexane
0.5 h; Ambient temperature; Yield given;
参考文献
Sugimoto, Akira; Kotani, Takeshi; Tsujimoto, Junko; Yoneda, Shigeo
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 435 - 438
