1-(2-氯乙基)哌啶盐酸盐合成路线 （共 58 条）
反应条件
hydrogenchloride; potassium carbonate in water
参考文献
Eli Lilly and Company
Patent: US5631369 A1, 1997 ;
反应条件
1: potassium carbonate / acetone / Heating 2: aq. sodium hydroxide; HCl / ethanol / 2 h / Heating View Scheme
参考文献
Das, Umashankar; Singh, Ravi S.P.; Alcorn, Jane; Hickman, Mark R.; Sciotti, Richard J.; Leed, Susan E.; Lee, Patricia J.; Roncal, Norma; Dimmock, Jonathan R.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 23 p. 7250 - 7256
反应条件
1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 16 h / 20 °C 1.2: 2 - 51 °C 2.1: boron trichloride / dichloromethane / 52.25 h / 2 - 20 °C 2.2: 1.08 h / 12 °C / Reflux View Scheme
参考文献
HEXAL AKTIENGESELLSCHAFT; SCHICKANEDER, Christian; SCHAeFER, Juergen
Patent: WO2011/47877 A1, 2011 ;
反应条件
potassium carbonate in acetone 6 h; Heating;
参考文献
Meegan; Hughes; Lloyd; Williams; Zisterer
Journal of Medicinal Chemistry, 2001 , vol. 44, # 7 p. 1072 - 1084
反应条件
in N,N-dimethyl-formamide
参考文献
Cereda, Enzo; Maiocchi, Luciano; Brambilla, Alessandro; Giraldo, Ettore; Monferini, Eugenia; Schiavi, Giovanni Battista
Patent: US2003/27823 A1, 2003 ;
反应条件
in water T=20°C; Alkylation; 2 h;
参考文献
Ronsisvalle, Giuseppe; Marrazzo, Agostino; Prezzavento, Orazio; Pasquinucci, Lorella; Falcucci, Barbara; Di Toro, Rosanna; Spampinato, Santi
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 6 p. 1503 - 1513
反应条件
ethanol; potassium carbonate
参考文献
Wadia et al.
Journal of Scientific and Industrial Research, 1958 , vol. 17B, p. 11,20
Chem.Abstr., 1958 , p. 15547
反应条件
hydrogen fluoride T=8 - 12°C; 5.58333 h; electrochemical fluorination: nickel electrodes, anodic current density: 4.0 A/dm2, cell voltage 5.6 - 6.7 V;
参考文献
Hayashi, Eiji; Abe, Takashi; Baba, Hajime; Nagase, Shunji
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 371 - 382
反应条件
1: 82 percent / K2CO3 / dimethylformamide / 1 h / Heating 2: 74 percent / AlCl3, EtSH / 1,2-dichloro-ethane / 2.5 h / 0 °C View Scheme
参考文献
Jones, Charles D.; Blaszczak, Larry C.; Goettel, Mary E.; Suarez, Tulio; Crowell, Thomas A.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 931 - 938
反应条件
1: aq. potassium carbonate / 1,2-dimethoxy-ethane / 24 h / 20 °C 2: H2 / Pd/C / ethanol / 16 h / 760 Torr View Scheme
参考文献
Goodacre, Caroline J.; Bromidge, Steven M.; Clapham, David; King, Frank D.; Lovell, Peter J.; Allen, Mike; Campbell, Lorraine P.; Holland, Vicky; Riley, Graham J.; Starr, Kathryn R.; Trail, Brenda K.; Wood, Martyn D.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4989 - 4993
