1-(2-氯乙基)哌啶盐酸盐合成路线 （共 58 条）
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in dichloromethane; water T=20°C; 120 h;
参考文献
Varga, Marton; Kapui, Zoltan; Batori, Sandor; Nagy, Lajos T.; Vasvari-Debreczy, Lelle; Mikus, Endre; Urban-Szabo, Katalin; Aranyi, Peter
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 421 - 425
反应条件
sodium azide in water T=80°C; 24 h;
参考文献
Xiao, Chunsheng; Cheng, Yilong; Zhang, Yu; Ding, Jianxun; He, Chaoliang; Zhuang, Xiuli; Chen, Xuesi
Journal of Polymer Science, Part A: Polymer Chemistry, 2014 , vol. 52, # 5 p. 671 - 679
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 100 °C 2: sodium hydroxide / methanol / 15 h / 20 °C 3: thionyl chloride / Reflux View Scheme
参考文献
Sabatini, Stefano; Gosetto, Francesca; Manfroni, Giuseppe; Tabarrini, Oriana; Kaatz, Glenn W.; Patel, Diixa; Cecchetti, Violetta
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5722 - 5736
反应条件
potassium carbonate; sodium iodide in acetone 18 h; Reflux;
参考文献
Huang, Jing; Li, Guorui; Wu, Zhiguo; Song, Zhibin; Zhou, Yangyang; Shuai, Liang; Weng, Xiaocheng; Zhou, Xiang; Yang, Guangfu
Chemical Communications, 2009 , # 8 p. 902 - 904
反应条件
Ki in methanol; chloroform; N,N-dimethyl-formamide
参考文献
Eli Lilly and Company
Patent: US5958917 A1, 1999 ;
反应条件
sodium ethanolate in ethanol 8 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 24, p. 185 - 188
反应条件
potassium carbonate in water
参考文献
Hickmott, Peter W.; Wood, Simon; Murray-Rust, Peter
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2033 - 2038
参考文献
Soc. Usines Chim. Rhone-Poulenc
Patent: DE833650 , 1950 ;
DRP/DRBP Org.Chem.
反应条件
1: With potassium carbonate in water
2: With hydrazine hydrate
1 h; Reflux;
参考文献
Wolf, Barbara M.T.; Eller, Gernot A.; Holzer, Wolfgang
Heterocycles, 2008 , vol. 75, # 8 p. 2035 - 2042
反应条件
1: 65 percent / K2CO3 / acetonitrile / 8 h / Heating
2: 90 percent / 2 N HCl / 5 h / Heating
3: 64 percent / toluene / 5 h / Ambient temperature
View Scheme
参考文献
Bourgery, Guy; Dostert, Philippe; Lacour, Alain; Langlois, Michel; Pourrias, Bernard; Tisne-Versailles, Jacky
Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 159 - 167
