1-(2-氯乙基)哌啶盐酸盐合成路线 （共 58 条）
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide
T=20 - 50°C; 15 h; Industry scale;
2: With sodium carbonate in tert-butyl methyl ether; water; N,N-dimethyl-formamide
T=20 - 30°C; Industry scale;
参考文献
Saindane, Manohar; Ge, Chuansheng
Patent: US2006/258706 A1, 2006 ;
Location in patent: Page/Page column 17; 18 ;
参考文献
Moussalli et al.
Patent: US2641598 , 1949 ;
Full Text Show Details
Moussalli et al.
Patent: DE870109 , 1950 ;
反应条件
tetrabutylammomium bromide; sodium hydroxide in methanol; dichloromethane; water
T=20°C; 16 h; Product distribution / selectivity;
参考文献
Hexal AG
Patent: EP2314581 A1, 2011 ;
Location in patent: Page/Page column 46-48 ;
反应条件
in dichloromethane; water
T=16 - 20°C; 6.5 h; Reflux; Product distribution / selectivity;
参考文献
Hexal AG
Patent: EP2322519 A1, 2011 ;
Location in patent: Page/Page column 26 ;
反应条件
potassium carbonate in isopropanol acetate; water
参考文献
Eli Lilly and Company
Patent: US5631369 A1, 1997 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C; 1.5 h;
参考文献
Luke, Wayne Douglas
Patent: US2005/137396 A1, 2005 ;
Location in patent: Page/Page column 4-7 ;
反应条件
1: K2CO3 / dimethylformamide / 1.5 h / 100 °C
2: 5 N aq. NaOH / methanol / 48 h
View Scheme
参考文献
Sabatini, Stefano; Gosetto, Francesca; Manfroni, Giuseppe; Tabarrini, Oriana; Kaatz, Glenn W.; Patel, Diixa; Cecchetti, Violetta
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5722 - 5736
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
Kuethe, Jeffrey T.; Wong, Audrey; Davies, Ian W.
Organic Letters, 2003 , vol. 5, # 21 p. 3975 - 3978
反应条件
1: 4-[4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl]-phenol With potassium carbonate in N,N-dimethyl-formamide
T=0°C;
2: N-(2-chloroethyl)-piperidine hydrochloride With tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide
T=50°C;
参考文献
Malo-Forest, Bianca; Landelle, Gregory; Roy, Jessye-Ann; Lacroix, Jacques; Gaudreault, Rene C.; Paquin, Jean-Francois
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1712 - 1715
反应条件
1.1: potassium carbonate / acetone / 3 h / 56 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -76 - -73 °C / |Inert atmosphere
2.2: 8 h / -78 °C / |Inert atmosphere
3.1: hydrogenchloride / dichloromethane / 0.75 h / 10 - 15 °C / |Inert atmosphere
View Scheme
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Youells, Scott; Beish, Sandra; Hu, Zhiyong; Branum, Shawn; Jain, Nareshkumar; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 731 - 738
