1-(2-氯乙基)哌啶盐酸盐合成路线 （共 58 条）
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
T=20°C; 30 h;
参考文献
Kowalska, Teresa; Kowalski, Piotr; Bojarski, Andrzej J.; Duszynska, Beata
Acta Poloniae Pharmaceutica - Drug Research, 2004 , vol. 61, # 5 p. 361 - 366
反应条件
sodium iodide; methylamine in methanol
参考文献
Taiyo Pharmaceutical Industry Co., Ltd.
Patent: US4762927 A1, 1988 ;
参考文献
Yang, Donglai; Soulier, Jean-Louis; Sicsic, Sames; Mathe-Allainmat, Monique; Bremont, Beatrice; Croci, Tiziano; Cardamone, Rosanna; Aureggi, Giulio; Langlois, Michel
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 608 - 621
反应条件
potassium hydroxide; potassium iodide in water
12 h; Heating;
参考文献
Grassmann, Sven; Apelt, Joachim; Ligneau, Xavier; Pertz, Heinz H.; Arrang, Jean-Michel; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter; Stark, Holger
Archiv der Pharmazie, 2004 , vol. 337, # 10 p. 533 - 545
反应条件
ethanol; potassium carbonate
参考文献
Wadia et al.
Journal of Scientific and Industrial Research, 1958 , vol. 17B, p. 11,20
Chem.Abstr., 1958 , p. 15547
参考文献
Hager; Al-Jaleel
Journal of the American Pharmaceutical Association (1912-1977), 1955 , vol. 44, p. 654
反应条件
1: sodium; toluene
2: acetone; ethanol
View Scheme
参考文献
Fakstorp; Christiansen
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 350,352
反应条件
1: sodium; toluene
2: diethyl ether
View Scheme
参考文献
Fakstorp; Christiansen
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 350,352
