(R)-(+)-2-丁基丁二酸 4-叔丁酯合成路线 （共 4 条）
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran
T=0°C; 3 h;
参考文献
Levy, Daniel E.; Lapierre, France; Liang, Weisheng; Ye, Wenqing; Lange, Christopher W.; Li, Xiaoyuan; Grobelny, Damian; Casabonne, Marie; Tyrrell, David; Holme, Kevin; Nadzan, Alex; Galardy, Richard E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 199 - 223
反应条件
1: 1.) n-BuLi / 1.) THF, - 78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) RT, 1 h
2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) -40 deg C, 1 h
3: 76 percent / aq. H2O2, LiOH / tetrahydrofuran / 3 h / 0 °C
View Scheme
参考文献
Levy, Daniel E.; Lapierre, France; Liang, Weisheng; Ye, Wenqing; Lange, Christopher W.; Li, Xiaoyuan; Grobelny, Damian; Casabonne, Marie; Tyrrell, David; Holme, Kevin; Nadzan, Alex; Galardy, Richard E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 199 - 223
反应条件
1: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) -40 deg C, 1 h
2: 76 percent / aq. H2O2, LiOH / tetrahydrofuran / 3 h / 0 °C
View Scheme
参考文献
Levy, Daniel E.; Lapierre, France; Liang, Weisheng; Ye, Wenqing; Lange, Christopher W.; Li, Xiaoyuan; Grobelny, Damian; Casabonne, Marie; Tyrrell, David; Holme, Kevin; Nadzan, Alex; Galardy, Richard E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 2 p. 199 - 223
反应条件
1: With (S)-1-phenyl-ethylamine
Resolution of racemate;
2: With hydrogenchloride in water
Resolution of racemate;
参考文献
Zhang, Datong; Wang, Zongheng; Xu, Weiren; Sun, Fanggang; Tang, Lida; Wang, Jianwu
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2202 - 2210
