2-(6-氯己氧基)四氢-2H-吡喃合成路线 （共 23 条）
反应条件
pyridinium p-toluenesulfonate in dichloromethane T=21°C; 18 h;
参考文献
Descoteaux, Caroline; Leblanc, Valerie; Belanger, Geoffroy; Parent, Sophie; Asselin, Eric; Berube, Gervais
Steroids, 2008 , vol. 73, # 11 p. 1077 - 1089
反应条件
1: 6-chlorohexyl alcohol With toluene-4-sulfonic acid in dichloromethane 0.5 h; 2: 3,4-dihydro-2H-pyran in dichloromethane T=20°C; 15.5 h;
参考文献
ST-JEAN PHOTOCHIMIE INC.; INTERNATIONAL BUSINESS MACHINES CORPORATION (IBM)
Patent: WO2006/50609 A1, 2006 ;
Location in patent: Page/Page column 12-13 ;
反应条件
sodium bromide; 1,1-dibromomethane in N,N-dimethyl-formamide T=100°C; 4 h;
参考文献
Babler, James H.; Spina, Kenneth P.
Synthetic Communications, 1984 , vol. 14, # 14 p. 1313 - 1320
反应条件
lithium; lithium hydride 1.) THF, 4 h, 2.) THF, 17 h; Yield given. Multistep reaction;
参考文献
Caplin, Joseph; Tyman, John H. P.
Journal of Chemical Research, Miniprint, 1982 , # 2 p. 321 - 351
反应条件
sodium bromide; 1,1-dibromomethane in N,N-dimethyl-formamide T=100°C; 4 h;
参考文献
Babler, James H.; Spina, Kenneth P.
Synthetic Communications, 1984 , vol. 14, # 14 p. 1313 - 1320
反应条件
1: 1.) magnesium / 1.) THF, reflux, 1.5 h, 2.) reflux, 1 h. 2: 98.6 percent / acide phosphorique / 180 - 200 °C View Scheme
参考文献
Barbry, Didier; Hasiak, Bruno
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # l p. 1734 - 1744
反应条件
1.1: 98 percent / dimethylsulfoxide / 3 h / 20 °C 2.1: zirconocene chloride hydride / benzene / 6 h / 20 °C 2.2: 71 percent / I2 / benzene 3.1: Pd(PPh3)4 / benzene / 0.25 h / 20 °C 3.2: 70 percent / benzene / 20 °C 4.1: 80 percent / PPTs / methanol / 24 h / 20 °C 5.1: 82 percent / pyridine / 12 h / 20 °C View Scheme
参考文献
Yen, Yao-Pin; Chen, Pao-Hsing
Journal of the Chinese Chemical Society, 1999 , vol. 46, # 1 p. 87 - 90
反应条件
lithium amide hexamethylphosphoroamide, 1.) 1h, room temperature, 2.) 10 h, 55 deg C; Multistep reaction;
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1: 1.) 2M BuLi / 1.) hexane, HMPT, 0 deg C, 30 min, 2.)THF, r. t., 12 h
2: p-TsOH / methanol / 2 h / Heating
3: 95 percent / H2, quinoline / Lindlar catalyst / pentane / 1 h / -10 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1: 1.) 2M BuLi / 1.) hexane, HMPT, 0 deg C, 30 min, 2.)THF, r. t., 12 h
2: p-TsOH / methanol / 2 h / Heating
3: 90 percent / LiAlH4 / 1,2-dimethoxy-ethane / 48 h / 140 °C
View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
