1: 1.) aq. KOH, AcOH; 2.) pyridine; 3.) DBU / 1.) THF, 4 deg C, 16 h; 2.) CH2Cl2, RT, overnight; 3.) benzene, 20 h 2: NaOH / tetrahydrofuran; H2O / 12 h View Scheme

1: 1) 10:1 formic acid-acetic anhydride; 2) sodium methoxide / 1) 12h, 25 deg C; 2) methanol, 2h, 25 deg C 2: lead tetraacetate / CH2Cl2 / 0.33 h / 78 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: LiOH / tetrahydrofuran; H₂O / 25 &deg;C<br />2: diethyl ether<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: KI₃, KHCO₃ / tetrahydrofuran; H₂O / 0 &deg;C<br />2: LiOH / tetrahydrofuran; H₂O / 25 &deg;C<br />3: diethyl ether<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342938', constants.ctx, '0')">lithium hydroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '15600254', constants.ctx, '0')">I₂</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '4535309', constants.ctx, '0')">potassium hydrogencarbonate</a> <br />&nbsp;1.) THF, H₂O, 2.) THF, H₂O;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a> <br />5&nbsp;h;&nbsp;&nbsp;Heating / reflux;&nbsp;<br /> &nbsp;