1: With sodium carbonate in 1,4-dioxane; water T=20°C; 8 h; 2: With hydrogenchloride in 1,4-dioxane; water

1: N-ethyl-N,N-diisopropylamine / acetonitrile; methanol / 1 h / 20 °C 2: sodium hydroxide / water; methanol / 1 h / 20 °C 3: dichloromethane / 3 h / 20 °C 4: sodium carbonate / water; 1,4-dioxane / 8 h / 20 °C View Scheme

1: dichloromethane / 3 h / 20 °C 2: sodium carbonate / water; 1,4-dioxane / 8 h / 20 °C View Scheme