(R)-2-(氰基甲基)吡咯烷-1-甲酸叔丁酯合成路线 （共 12 条）
反应条件
in dimethyl sulfoxide T=90°C; 7 h;
参考文献
US2009/203763 A1, ;
Page/Page column 33 ;
US 20090203763 A1
反应条件
1: pyridine / 1 h 2: 1.35 g / dimethylsulfoxide / 3 h / 80 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 22 p. 7126 - 7127
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 8 p. 3455 - 3461
反应条件
in N,N-dimethyl-formamide T=100°C; Substitution; 6 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 3 p. 342 - 345
反应条件
1: CH2Cl2 / 1 h 2: pyridine / 1 h 3: 1.35 g / dimethylsulfoxide / 3 h / 80 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 22 p. 7126 - 7127
反应条件
in dimethyl sulfoxide T=90°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 12 p. 2571 - 2578
反应条件
1: CH2Cl2 / 1 h 2: pyridine / 1 h 3: 1.35 g / dimethylsulfoxide / 3 h / 80 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 22 p. 7126 - 7127
反应条件
in dimethyl sulfoxide T=80°C; 3 h;
参考文献
Journal of the American Chemical Society, , vol. 128, # 22 p. 7126 - 7127
反应条件
1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -5 °C 2: 0.53 g / I2; NaBH4 / tetrahydrofuran / 5.5 h / 0 - 20 °C 3: 78 percent / TEA; DMAP / CH2Cl2 / 3 h / 0 °C 4: 60 percent / dimethylsulfoxide / 4 h / 90 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 12 p. 2571 - 2578
反应条件
1: sodium tetrahydroborate 2: triethylamine 3: 95 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 8 p. 3455 - 3461
