2-(4-氯苯基)-3-甲基丁酸合成路线 （共 15 条）
反应条件
1: 100 percent / SOCl2 / benzene 2: 94.7 percent / benzene; pyridine View Scheme
参考文献
Volkov, Yu. P.; Kalinevich, V. M.; Trusova, E. I.; Bilevich, K. A.; Kryshtal', G. V.; Yanovskaya, L. Ya.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 6 p. 1239 - 1242
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 6 p. 1365 - 1368
反应条件
thionyl chloride in benzene
参考文献
Volkov, Yu. P.; Kalinevich, V. M.; Trusova, E. I.; Bilevich, K. A.; Kryshtal', G. V.; Yanovskaya, L. Ya.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 6 p. 1239 - 1242
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 6 p. 1365 - 1368
反应条件
2,4,6-trimethyl-pyridine; oxalyl dichloride in N,N-dimethyl-formamide T=-15°C; 2 h;
参考文献
Wang, Yingcai; Jiao, Xianyun; Kayser, Frank; Liu, Jiwen; Wang, Zhongyu; Wanska, Malgorzata; Greenberg, Joanne; Weiszmann, Jennifer; Ge, Hongfei; Tian, Hui; Wong, Simon; Schwandner, Ralf; Lee, Taeweon; Li, Yang
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 493 - 498
反应条件
1: via (S)-(-)-α-methylbenzylamine salt 2: SOCl2; DMF / CHCl3 / 1 h / 60 °C 3: 495 mg / pyridine / CH2Cl2 / 0.5 h View Scheme
参考文献
Shan, Guomin; Stoutamire, Donald W.; Wengatz, Ingrid; Gee, Shirley J.; Hammock, Bruce D.
Journal of Agricultural and Food Chemistry, 1999 , vol. 47, # 5 p. 2145 - 2155
反应条件
1: via (R)-(+)-α-methylbenzylamine salt
2: SOCl2; DMF / CHCl3 / 1 h / 60 °C
3: 441 mg / pyridine / CH2Cl2 / 0.5 h
View Scheme
参考文献
Shan, Guomin; Stoutamire, Donald W.; Wengatz, Ingrid; Gee, Shirley J.; Hammock, Bruce D.
Journal of Agricultural and Food Chemistry, 1999 , vol. 47, # 5 p. 2145 - 2155
