3-甲基-1H-吲哚-6-羧酸合成路线 (共 2 条)
反应条件
lithium hydroxide in methanol T=70°C;
参考文献
Hulme, Christopher; Moriarty, Kevin; Miller, Bruce; Mathew, Rose; Ramanjulu, Mercy; Cox, Paul; Souness, John; Page, Ken M.; Uhl, Joanne; Travis, Jeffrey; Huang, Fu-Chih; Labaudiniere, Richard; Djuric, Stevan W.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1867 - 1872
反应条件
1: 1.) p-toluenesulfonic acid, p-toluenesulfonyl hydrazide, sulfolane, 2.) NaCNBH3 / 1.) DMF, 100 deg C, 2.) DMF, 100 deg C, 2 h 2: 90 percent / aq. LiOH / methanol / 70 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 14 p. 1867 - 1872