3-甲基-1H-吲唑-6-羧酸合成路线 (共 2 条)
反应条件
1: 3-Amino-4-ethyl benzoic acid With boron trifluoride diethyl etherate in tetrahydrofuran; chloroform T=-12°C; 0.333333 h; 2: tert.-butylnitrite in tetrahydrofuran; chloroform T=5°C; 1.5 h; 3: With potassium acetate; 18-crown-6 ether in tetrahydrofuran; chloroform T=20°C; 40 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6348474 B1, 2002 ;
Location in patent: Page column 80,81 ;
反应条件
1: With water; potassium carbonate in methanol 2 h; Heating / reflux; 2: With potassium hydrogensulfate in water pH=3 - 3.5;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65508 A1, 2008 ;
Location in patent: Page/Page column 30-31 ;