1: triethylamine / dichloromethane / 3 h / Inert atmosphere 2: toluene-4-sulfonic acid / tetrahydrofuran; water / 20 °C 3: Grubb's 2nd generation catalyst / dichloromethane / 6 h / 50 °C / Inert atmosphere 4: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 5: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 6: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme

1: toluene-4-sulfonic acid / tetrahydrofuran; water / 20 °C 2: Grubb's 2nd generation catalyst / dichloromethane / 6 h / 50 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 4: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 5: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme

1: Grubb's 2nd generation catalyst / dichloromethane / 6 h / 50 °C / Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 3: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 4: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme

1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 2: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme

1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 36 h / 50 °C 3: triethylamine / dichloromethane / 3 h / Inert atmosphere 4: toluene-4-sulfonic acid / tetrahydrofuran; water / 20 °C 5: Grubb's 2nd generation catalyst / dichloromethane / 6 h / 50 °C / Inert atmosphere 6: palladium 10 on activated carbon; hydrogen / ethyl acetate / 2 h 7: 1H-imidazole; iodine; triphenylphosphine / diethyl ether; acetonitrile / 0 °C / Inert atmosphere 8: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere View Scheme

hydrogen; palladium on activated charcoal in ethanol 10 h;

hydrogen; palladium on activated charcoal in ethanol 10 h;