1.1: 77 percent / mesyl chloride; triethylamine / CH2Cl2 / 2.5 h / -20 - 40 °C 2.1: t-BuLi / tetrahydrofuran / 0.75 h / -78 - 0 °C 2.2: 85 percent / TMEDA / tetrahydrofuran / 12 h / 20 °C 3.1: ThxBH2 / tetrahydrofuran / 16 h / 0 °C 3.2: 59 percent / aq. NaOH; aq. H2O2 / 6 h / 20 °C 4.1: 93 percent / TBAF / tetrahydrofuran / 2 h / 0 - 20 °C 5.1: 74 percent / triphenylphosphine; iodine; imidazole / toluene / 3 h / 70 °C 6.1: 92 percent / ethanol / 3 h / Heating View Scheme

1: CCl4, tris(dimethylamino)phosphane / tetrahydrofuran / 4 h / -80 °C 2: 20 percent / KOH, tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile / 0.5 h / Ambient temperature 3: 82 percent / Bu4NF / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme

1: CCl4, tris(dimethylamino)phosphane / tetrahydrofuran / 4 h / -80 °C 2: 29 percent / KOH, tris<2-(2-methoxyethoxy)ethyl>amine / acetonitrile / 0.5 h / Ambient temperature 3: 54 percent / Bu4NF / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme