1.1: bis-(trifluoromethylsulphonyl)amine / dichloromethane; toluene / 0.08 h / 20 °C / Inert atmosphere 2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere 2.2: 1.5 h / -78 - 20 °C / Inert atmosphere 3.1: bis-(trifluoromethylsulphonyl)amine / dichloromethane; toluene / 0.08 h / -10 °C / Inert atmosphere View Scheme

1.1: bis-(trifluoromethylsulphonyl)amine / dichloromethane; toluene / 0.08 h / -10 °C / Inert atmosphere 2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere 2.2: 1.5 h / -78 - 20 °C / Inert atmosphere 3.1: bis-(trifluoromethylsulphonyl)amine / dichloromethane; toluene / 0.08 h / -10 °C / Inert atmosphere View Scheme

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere 1.2: 1.5 h / -78 - 20 °C / Inert atmosphere 2.1: bis-(trifluoromethylsulphonyl)amine / dichloromethane; toluene / 0.08 h / -10 °C / Inert atmosphere View Scheme

bis-(trifluoromethylsulphonyl)amine in toluene T=20°C; 1 h;

bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; Domino Michael addition - Claisen condensation; 1 h;

bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; Flow microreactor; optical yield given as percent dediastereoselective reaction;

boron trifluoride diethyl etherate in dichloromethane -70 deg C to -30 deg C;

bis-(trifluoromethylsulphonyl)amine in dichloromethane T=20°C; 1 h;