2-(N-苄基-4-甲基苯基磺酰胺)乙酸合成路线 （共 16 条）
反应条件
1: With sodium hydroxide in methanol 1 h; Reflux; 2: With hydrogenchloride in water T=20°C; pH=2;
参考文献
Ramunno, Anna; Cosconati, Sandro; Sartini, Stefania; Maglio, Vita; Angiuoli, Sara; La Pietra, Valeria; Di Maro, Salvatore; Giustiniano, Mariateresa; La Motta, Concettina; Da Settimo, Federico; Marinelli, Luciana; Novellino, Ettore
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 216 - 226
反应条件
hydrogenchloride; triethylamine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Stranix, Brent Richard; Sauve, Gilles; Bouzide, Abderrahim; Cote, Alexandre; Berube, Gervais; Soucy, Patrick; Zhao, Yongsen; Yelle, Jocelyn
Patent: US2002/151546 A1, 2002 ;
反应条件
1: NaHCO3 / acetone; H2O / 20 °C 2: Et3N / acetonitrile / 2 h / Heating View Scheme
参考文献
Rozhkov, V. S.; Sladkov, V. I.; Turdybekov, K. M.; Lindeman, S. V.; Kolesnikov, A. Yu.; et al.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 6.2 p. 1162 - 1167
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 6 p. 1292 - 1298
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Caldarelli, Marina; Habermann, Joerg; Steven V, Ley
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 2049 - 2052
反应条件
triethylamine in acetonitrile Alkylation; 2 h; Heating;
参考文献
Scozzafava, Andrea; Supuran, Claudiu T.
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 3 p. 299 - 307
反应条件
1: 89 percent / polymer-supported phosphazene-BEMP on polystyrene / CH2Cl2 2: TFA / CH2Cl2 View Scheme
参考文献
Caldarelli, Marina; Habermann, Joerg; Steven V, Ley
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 2049 - 2052
反应条件
1: 89 percent / polymer-supported phosphazene-BEMP on polystyrene / CH2Cl2 2: TFA / CH2Cl2 View Scheme
参考文献
Fischer,E.; v.Mechel
Chemische Berichte, 1916 , vol. 49, p. 1361
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 2.1: sodium hydroxide / methanol / 1 h / Reflux 2.2: 20 °C / pH 2 View Scheme
参考文献
Ramunno, Anna; Cosconati, Sandro; Sartini, Stefania; Maglio, Vita; Angiuoli, Sara; La Pietra, Valeria; Di Maro, Salvatore; Giustiniano, Mariateresa; La Motta, Concettina; Da Settimo, Federico; Marinelli, Luciana; Novellino, Ettore
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 216 - 226
反应条件
1.1: triethylamine / dichloromethane / 0 - 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C 3.1: sodium hydroxide / methanol / 1 h / Reflux 3.2: 20 °C / pH 2 View Scheme
参考文献
Ramunno, Anna; Cosconati, Sandro; Sartini, Stefania; Maglio, Vita; Angiuoli, Sara; La Pietra, Valeria; Di Maro, Salvatore; Giustiniano, Mariateresa; La Motta, Concettina; Da Settimo, Federico; Marinelli, Luciana; Novellino, Ettore
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 216 - 226
反应条件
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 20 °C 2: lithium hydroxide hydrate / methanol; tetrahydrofuran; water / 20 °C View Scheme
参考文献
Urlam, Murali K.; Pireddu, Roberta; Ge, Yiyu; Zhang, Xiaolei; Sun, Ying; Lawrence, Harshani R.; Guida, Wayne C.; Sebti, Said M.; Lawrence, Nicholas J.
MedChemComm, 2013 , vol. 4, # 6 p. 932 - 941
