1.1: potassium carbonate / water; acetone / 20 °C 1.2: 17 h / Reflux 2.1: bromine / acetic acid / 20 °C 3.1: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; sodium formate / water / 2 h / 20 - 40 °C / Inert atmosphere 4.1: 5 platinum on carbon; dimethylsulfide; hydrogen / tetrahydrofuran / 12 h / 40 °C / 25858.1 Torr 5.1: acetic anhydride / tetrahydrofuran / 1 h / 10 - 20 °C View Scheme

1: N-[5-((1R)-2-bromo-1-hydroxyethyl)-2-(phenylmethoxy)phenyl]carboxamide; (R)-N-benzyl-N-(1-methyl-2-p-methoxyphenylethyl)amine L-mandelate With potassium carbonate in tetrahydrofuran; methanol T=25°C; Inert atmosphere; 2: T=120°C; 24 h; Inert atmosphere; 3: (2E)-but-2-enedioic acid Further stages;