3-(3,5-二叔丁基-4-羟基苯基)丙酸合成路线 （共 16 条）
反应条件
sulfuric acid 16 h; Reflux;
参考文献
Jones, Kevin M.; Hillringhaus, Tim; Klussmann, Martin
Tetrahedron Letters, 2013 , vol. 54, # 25 p. 3294 - 3297
参考文献
Prokopov; Berlyand; Veselovskaya; Ufimtseva; Belova; Shukil
Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 5 p. 273 - 275
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction; Heating;
参考文献
Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782
反应条件
1.1: sulfuric acid / 16 h / |Reflux
2.1: 5,15,10,20-tetraphenylporphyrin; oxygen / chloroform / 16 h / 20 °C / |Irradiation
3.1: triphenylphosphine / chloroform / 0.33 h / 20 °C
3.2: 4 h / 50 °C
View Scheme
参考文献
Jones, Kevin M.; Hillringhaus, Tim; Klussmann, Martin
Tetrahedron Letters, 2013 , vol. 54, # 25 p. 3294 - 3297
反应条件
1: LAH / tetrahydrofuran
2: PBr3; Pyr
View Scheme
参考文献
Aubriot, Silvere; Nicolle, Edwige; Lattier, Mireille; Morel, Cecile; Cao, Wenhong; Daniel, Kiefer W.; Collins, Sheila; Leclerc, Gerard; Faure, Patrice
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 209 - 212
反应条件
in xylene
T=130°C; 7 h; 60 deg C, 6 h; Product distribution;
参考文献
Dominina, N. S.; Gorokhova, L. S.; Shagov, V. S.
J. Appl. Chem. USSR (Engl. Transl.), 1982 , vol. 55, # 4 p. 884 - 889,810 - 814
