copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in diisopropylamine; toluene T=40°C; 7 h;

tri-tert-butyl phosphine; argon; hydrogen; potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide in tetrahydrofuran; hexane Sonogashira-Hagihara cross-coupling; Heating;

1: anhydrous 1-octyne With n-butyllithium in tetrahydrofuran; hexane T=0°C; 2: With zinc dibromide in tetrahydrofuran; hexane T=0°C; 3: 4-fluorobenzenecarbonitrile With n-tridecane; [NiCl2(PMe3)2] in tetrahydrofuran T=65°C; 45 h; Further stages.;