N-苄氧羰基-L-亮氨酸合成路线 （共 125 条）
反应条件
Yield given. Multistep reaction;
参考文献
Fleming, Ian; Lawrence, Nicholas J.
Tetrahedron Letters, 1990 , vol. 31, # 25 p. 3645 - 3648
反应条件
1: 1.) isobutylchloroformate, N-ethylmorpholine, 2.) ammonia / 1.) -15 deg C, 5 min, 2.) -15 deg C, 30 min 2: 1.) 5percent Pd/C / 1.) 80percent glacial acetic acid, overnight, 2.) pyridine View Scheme
参考文献
Kent, Hilary E.; Lilley, Terence H.; Milburn, Peter J.; Bloemendal, Michael; Somsen, Gus
Journal of Solution Chemistry, 1985 , vol. 14, # 2 p. 101 - 116
反应条件
1: 1.) HOSu, DCCD 2.) triethylamine / 1.) chloroform, 0 deg C, 4 h 2.) chloroform, DMF, 2 d, room temp. 2: hydrogen / palladium / methanol / 4.5 h 3: triethylamine / dimethylformamide; H2O / 72 h / Ambient temperature; pH=8.0 4: 1N HCl / acetonitrile / 2 h / 37 °C View Scheme
参考文献
Saino; Someno; Miyazaki; Ishii
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2319 - 2325
反应条件
1: PTSA / benzene 2: H2 / 10percent Pd/C / methanol View Scheme
参考文献
Reddy, G. Vidyasagar; Rao, G. Venkat; Iyengar
Tetrahedron Letters, 1998 , vol. 39, # 14 p. 1985 - 1986
反应条件
1: unter Zusatz von Cystein und Papain in gepufferter wss.Loesung <pH 5> 2: palladium; methanol.HCl / Hydrogenation View Scheme
参考文献
Journal of Biological Chemistry, , vol. 119, p. 707,717
反应条件
1: PCl5; CHCl3 / Behandeln des Reaktionsprodukts mit L-Prolin-methylester und wss. KHCO3 in CHCl3 2: palladium; aqueous methanol. acetic acid / Hydrogenation.Erwaermen der Reaktionsloesung View Scheme
参考文献
Stoll et al.
Helvetica Chimica Acta, 1951 , vol. 34, p. 1544,1575
反应条件
1: toluene; chlorocarbonic acid isobutyl ester 2: palladium; acetic acid; aqueous methanol / Hydrogenolyse View Scheme
参考文献
Izumiya et al.
Nippon Kagaku Zasshi, 1958 , vol. 79, p. 420,423
Chem.Abstr., 1960 , p. 4408
反应条件
citrate buffer; dl-cysteine hydrochloride; papain T=50°C; 24 h;
参考文献
Moriniere, Jean-Luc; Danree, Bernard; Guy, Alain
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 347 - 358
反应条件
D,L-Cysteine; papain T=40°C; gepufferte wss. Loesung (pH 5);
参考文献
Bergmann; Fraenkel-Conrat
Journal of Biological Chemistry, 1937 , vol. 119, p. 707,717
反应条件
resolved on CSP cellulose tris(3,5-dimethylphenylcarbamate) by chiral HPLC;
参考文献
Okamoto, Yoshio; Aburatani, Ryo; Kaida, Yuriko; Hatada, Koichi
Chemistry Letters, 1988 , p. 1125 - 1128
