1: 69.5 percent / H2O, phosphate buffer pH=7, pig panereatic lipase, aq. NaOH / diisopropyl ether / 4.33 h / 20 °C 2: CF3COOH / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) RT, 2 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NaH / 1.) THF, hexane, from -30 deg C to 0 deg C, 1 h, 2.) THF, 0 deg C, 2 h<br />2: 92 percent / H₂, (PPh₃)3RhCl / ethanol; benzene / 48 h / 3800 Torr / Ambient temperature<br /> <br /> &nbsp;