1-溴-3-氯-2,4-二氟苯合成路线 (共 7 条)
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-20 - 0°C; 0.0833333 h; 2: 2,4-difluoro-1-bromobenzene in tetrahydrofuran; hexane T=-78 - -65°C; 2 h; 3: With 1,1,1,3,3,3-hexachloro-propan-2-one in tetrahydrofuran; hexane T=-65 - 20°C;
参考文献
THE PROCTER and GAMBLE COMPANY
Patent: WO2004/14893 A2, 2004 ;
Location in patent: Page 79 ;
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
参考文献
The Procter and Gamble Co.
Patent: US6329391 B1, 2001 ;
反应条件
1: n-butyllithium; diisopropylamine in tetrahydrofuran T=-20 - 0°C; 0.0833333 h; 2: T=-78°C; 3: 2,4-difluoro-1-bromobenzene With 1,1,1,3,3,3-hexachloro-propan-2-one more than 3 stages;
参考文献
The Procter and Gamble Co.
Patent: US6348624 B1, 2002 ;
Location in patent: Page column 10 ;
反应条件
1: 3-Chloro-2,4-difluoro-bromobenzene in diethyl ether Cooling with acetone-dry ice; 2: n-butyllithium in hexane T=-65°C; 0.75 h; 3: carbon dioxide T=-65 - 20°C;
参考文献
The Procter and Gamble Co.
Patent: US6348624 B1, 2002 ;
Location in patent: Page column 11 ;
反应条件
1: 3-Chloro-2,4-difluoro-bromobenzene With n-butyllithium in diethyl ether T=-78 - -70°C; 0.25 h; 2: carbon dioxide T=-70°C;
参考文献
THE PROCTER and GAMBLE COMPANY
Patent: WO2004/14893 A2, 2004 ;
Location in patent: Page 79; 80 ;
反应条件
hydrogenchloride; n-butyllithium; CO2 in water
参考文献
The Procter and Gamble Co.
Patent: US6329391 B1, 2001 ;
反应条件
hydrogenchloride; n-butyllithium in water
参考文献
The Procter and Gamble Company
Patent: US2002/49192 A1, 2002 ;