(3R,4S)-3-(1-乙氧基乙氧基)-4-苯基-2-氮杂环丁酮合成路线 （共 9 条）
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
in tetrahydrofuran; hexane; acetone
参考文献
Florida State University
Patent: US5015744 A1, 1991 ;
反应条件
1: 100 percent / NBu4F / tetrahydrofuran 2: 100 percent / H(1+) View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
1: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 2: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 3: 100 percent / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
1: 1. hexamethyldisilazane, n-BuLi / 1. THF, hexane, reflux, 3 h; 2. reflux, 2 h 2: 1. diisopropylamine, n-butyllithium / 1. THF, 2 h; 2. THF a.) -78 deg C, 4 h, b.) r.t. 3: 81 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.42 h / Ambient temperature 4: 100 percent / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
1: 92 percent / DMAP, triethylamine / CH2Cl2 / 2 h / 25 °C 2: 40 percent / NaH / tetrahydrofuran / 3 h / 35 °C 3: 88 percent / 0.5percent hydrochloric acid / ethanol / 48 h / 0 °C View Scheme
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=25°C; 2 h;
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
n-butyllithium in tetrahydrofuran; hexane
参考文献
Florida State University
Patent: US5175315 A1, 1992 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
参考文献
Ojima, Iwao; Sun, Chung Ming; Zucco, Martine; Park, Young Boon; Duclos, Olivier; Kuduk, Scott
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4149 - 4152
