4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide T=20°C; 16 h;

in pyridine; dichloromethane

1: sodium borohydride; BF3*Et2O / 3 h / Heating 2: 600 mg / DMAP / dimethylformamide / 15 h / 20 °C View Scheme

1: palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; caesium carbonate / tetrahydrofuran; N,N-dimethyl-formamide; water / 24 h / 80 °C / |Inert atmosphere 2: hydrogenchloride / methanol / 16 h / 20 °C 3: isopropylmagnesium chloride / tetrahydrofuran / 15 h / -20 - 20 °C View Scheme

tetrakis(triphenylphosphine) palladium(0); potassium acetate in dimethyl sulfoxide T=80°C;

triethanolamine; palladium diacetate in methanol; dimethyl sulfoxide

palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine in methanol; dimethyl sulfoxide T=80°C; 16 h;