4,5-二甲氧基靛红酸酐合成路线 （共 16 条）
反应条件
sodium carbonate in water; acetonitrile 2 h; Heating;
参考文献
Grosso, John A.; Nichols, David E.; Kohli, Jai D.; Glock, Dana
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 703 - 708
反应条件
hydrazine hydrate
Ambient temperature;
参考文献
Sircar, Jagadish C.; Capiris, Thomas; Kesten, Stephen J.; Herzig, David J.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 735 - 742
反应条件
in pyridine
0.5 h; Heating;
参考文献
Bergman, Jan; Bergman, Solveig
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1246 - 1255
反应条件
1: 6,7-dimethoxy-1H-benzo[d][1,3]oxazine-2,4-dione With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 0.5 h;
2: methyl iodide in N,N-dimethyl-formamide
T=0 - 20°C; 1 h;
参考文献
ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG
Patent: WO2008/52742 A1, 2008 ;
Location in patent: Page/Page column 20; Sheet 3; Sheet 7 ;
反应条件
(i) NaH, AcNMe2, (ii) methyl halide; Multistep reaction;
参考文献
Hardtmann; Koletar; Pfister
Journal of Heterocyclic Chemistry, 1975 , vol. 12, # 3 p. 565 - 572
反应条件
1: With pyridine
6 h; Reflux;
2: With acetic acid
T=130°C; 12 h;
参考文献
Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572
