(4-氰基-1H-1,2,3-噻唑-1-基)乙酸乙酯合成路线 （共 3 条）
反应条件
1: azido-acetic acid ethyl ester; alpha-chloroacrylonitrile in water T=80°C; 16 h; 2: ethanol With sulfuric acid 16 h; Reflux; 3: With sodium hydrogencarbonate in ethyl acetate
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2010/305085 A1, 2010 ;
Location in patent: Page/Page column 26 ;
US 20100305085 A1
参考文献
Novartis AG
Patent: US6156907 A1, 2000 ;
反应条件
in ethanol; water; ethyl acetate
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2009/269420 A1, 2009 ;
