3-甲基-2-氧代丁酰乙酯合成路线 （共 59 条）
反应条件
1: LiOH*H2O / tetrahydrofuran / 20 °C 2: 3.8 g / methanesulfonic acid / toluene / 2 h / Heating 3: 94 percent / H2; (-)-[4'-(PPh2)-2,2',5,5'-Me4-3,3'-bithien-4-yl]PPh2; Et3N / [(p-cymene)RuCl2]2 / ethanol; 1,2-dichloro-ethane / 24 h / 25 °C / 4654.33 Torr View Scheme
参考文献
Shultz, C. Scott; Dreher, Spencer D.; Ikemoto, Norihiro; Williams, J. Michael; Grabowski, Edward J. J.; Krska, Shane W.; Sun, Yongkui; Dormer, Peter G.; DiMichele, Lisa
Organic Letters, 2005 , vol. 7, # 16 p. 3405 - 3408
反应条件
(diethylamido)sulfur trifluoride T=25°C; 3 h;
参考文献
Parisi; Gattuso; Notti; Raymo; Abeles
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5174 - 5179
反应条件
hydrogenchloride; potassium hydroxide; sodium nitrite 1.) -5 deg C, 30 min, 2.) ethanol, water, 0 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Black, David St.C.; Deacon, Glen B.; Edwards, Gavin L.
Australian Journal of Chemistry, 1991 , vol. 44, # 12 p. 1771 - 1781
反应条件
hydrogen; chiral Ru complex T=20°C; P=25857.4 Torr; 100 h; Title compound not separated from byproducts;
参考文献
Qiu, Liqin; Kwong, Fuk Yee; Wu, Jing; Lam, Wai Har; Chan, Shusun; Yu, Wing-Yiu; Li, Yue-Ming; Guo, Rongwei; Zhou, Zhongyuan; Chan, Albert S. C.
Journal of the American Chemical Society, 2006 , vol. 128, # 17 p. 5955 - 5965
参考文献
Seifert et al.
Helvetica Chimica Acta, 1950 , vol. 33, p. 725,733
反应条件
toluene T=409.3°C; P=46.5 Torr; Kinetics; Further Variations:TemperaturesPressures;
参考文献
Reyes, Andreina; Dominguez, Rosa M.; Tosta, Maria; Herize, Armando; Chuchani, Gabriel
International Journal of Chemical Kinetics, 2007 , vol. 39, # 5 p. 268 - 275
反应条件
1: 70 percent / conc. sulfuric acid / benzene / 18 h / Heating
2: 90 percent / ammonia / ethanol
View Scheme
参考文献
Yates, Peter; Hoare, John Harold
Canadian Journal of Chemistry, 1983 , vol. 61, p. 1397 - 1404
反应条件
1: 1.) sodium hydride, 2.) potassium hydroxide / 1.) diethyl ether, -78 deg C, 3 h then room temperature, 2.) ethanol-water 1 : 1, reflux
2: 10 percent / Irradiation
View Scheme
参考文献
Eck, Richard; Simon, Helmut
Tetrahedron, 1994 , vol. 50, # 48 p. 13631 - 13640
反应条件
potassium hydroxide; sodium hydride
1.) diethyl ether, -78 deg C, 3 h then room temperature, 2.) ethanol-water 1 : 1, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Eck, Richard; Simon, Helmut
Tetrahedron, 1994 , vol. 50, # 48 p. 13631 - 13640
反应条件
hydroxylamine hydrochloride; sodium carbonate in methanol; water
T=0°C; 1.5 h;
参考文献
Mitani, Michiharu; Tanaka, Yasunori; Sawada, Akihiko; Misu, Ayuko; Matsumoto, Yoshihiro
European Journal of Organic Chemistry, 2008 , # 8 p. 1383 - 1391
