3-甲基-2-氧代丁酰乙酯合成路线 （共 59 条）
反应条件
(diethylamido)sulfur trifluoride
T=25°C; 3 h;
参考文献
Parisi; Gattuso; Notti; Raymo; Abeles
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5174 - 5179
反应条件
1: LiOH*H2O / tetrahydrofuran / 20 °C
2: 3.8 g / methanesulfonic acid / toluene / 2 h / Heating
View Scheme
参考文献
Shultz, C. Scott; Dreher, Spencer D.; Ikemoto, Norihiro; Williams, J. Michael; Grabowski, Edward J. J.; Krska, Shane W.; Sun, Yongkui; Dormer, Peter G.; DiMichele, Lisa
Organic Letters, 2005 , vol. 7, # 16 p. 3405 - 3408
反应条件
sulfuric acid
T=-10 - 0°C;
参考文献
Ramart-Lucas
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1912 , vol. 154, p. 1618
Annales de Chimie (Cachan, France), 1913 , vol. <8> 30, p. 411
参考文献
Ramart-Lucas
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1912 , vol. 154, p. 1618
Annales de Chimie (Cachan, France), 1913 , vol. <8> 30, p. 411
反应条件
potassium hydroxide; sodium hydride
1.) diethyl ether, -78 deg C, 3 h then room temperature, 2.) ethanol-water 1 : 1, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Eck, Richard; Simon, Helmut
Tetrahedron, 1994 , vol. 50, # 48 p. 13631 - 13640
反应条件
sodium tetrahydroborate in methanol
T=20°C; 0.166667 h;
参考文献
Kim, Juryoung; De Castro, Kathlia A.; Lim, Minkyung; Rhee, Hakjune
Tetrahedron, 2010 , vol. 66, # 23 p. 3995 - 4001
反应条件
sodium tetrahydroborate in methanol
T=20°C; 0.166667 h;
参考文献
Kim, Juryoung; De Castro, Kathlia A.; Lim, Minkyung; Rhee, Hakjune
Tetrahedron, 2010 , vol. 66, # 23 p. 3995 - 4001
反应条件
potassium hydroxide; sodium hydride
1.) diethyl ether, -78 deg C, 3 h then room temperature, 2.) ethanol-water 1 : 1, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Eck, Richard; Simon, Helmut
Tetrahedron, 1994 , vol. 50, # 48 p. 13631 - 13640
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / |Inert atmosphere
1.2: 2.08 h / 0 - 50 °C / |Inert atmosphere
2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 8 h / 0 - 20 °C
2.2: 0 °C
3.1: trifluoroacetic anhydride / 20 °C / |Inert atmosphere
View Scheme
参考文献
Aiwale, Sachin T.; Sardi, Paola; Dallavalle, Sabrina
Synthetic Communications, 2013 , vol. 43, # 10 p. 1455 - 1459
