6,7-二甲基-1H-吲哚-2,3-二酮合成路线 （共 8 条）
反应条件
methanesulfonic acid T=70 - 80°C; 1.25 h;
参考文献
US2008/255192 A1, ;
Page/Page column 15 ;
反应条件
1: hydroxylamine hydrochloride; sodium sulfate; aq. HCl / 55 °C 2: conc. sulfuric acid / 55 - 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 1 p. 21 - 39
反应条件
1: With hydrogenchloride; sodium sulfate pentahydrate; hydroxylammonium sulfate in water T=45 - 75°C; 2: With methanesulfonic acid T=75°C;
参考文献
Helvetica Chimica Acta, , vol. 95, # 12 p. 2446 - 2459
反应条件
Erwaermen des Reaktionsgemisches mit Aluminiumchlorid;
反应条件
potassium hydroxide; potassium chloride; dihydrogen peroxide T=20°C;
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 2: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 3: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C 4: 70 percent / concd. H2SO4 / H2O / 0.17 h / 80 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 2: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
反应条件
1: 65 percent / KOH, KCl, 27percent H2O2 / 20 °C 2: 1.) concd. H2SO4, NaNO2, 2.) KI / 1.) water, 10 deg C, 2.) 100 deg C 3: 63 percent / tris<2-(2-methoxyethoxy)ethyl>amine (TDA-1), CuCl / dimethylsulfoxide / 12 h / 95 °C View Scheme
参考文献
Rewcastle, Gordon W.; Atwell, Graham J.; Zhuang, Li; Baguley, Bruce C.; Denny, William A.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 217 - 222
