2-(4-溴丁基)-2-甲基-1,3-二氧戊环合成路线 （共 5 条）
反应条件
toluene-4-sulfonic acid in toluene Etherification; Cyclization; Heating;
参考文献
Chen; Huang; Fu; Cheng; Zhang; Li; Peng
Synthesis, 2000 , # 14 p. 2004 - 2008
反应条件
1: 86 percent / HBr; NaBr; H2SO4 / 50 °C 2: 92 percent / TsOH / toluene / Heating View Scheme
参考文献
Chen; Huang; Fu; Cheng; Zhang; Li; Peng
Synthesis, 2000 , # 14 p. 2004 - 2008
反应条件
1.1: potassium carbonate / chloroform / 0.25 h / 0 °C / Inert atmosphere 1.2: 2.5 h / 0 °C 2.1: toluene-4-sulfonic acid / 3 h / Inert atmosphere; Reflux View Scheme
参考文献
ACTELION
Patent: US2011/34516 A1, 2011 ;
US 20110034516 A1
反应条件
hydrogen bromide Multistep reaction;
参考文献
Khao, Nguen Kong; Mavrov, M. V.; Serebryakov, E. P.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 9 p. 1934 - 1937
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 9 p. 2083 - 2085
反应条件
1: K2CO3 / acetone; dimethylformamide / 24 h / Heating 2: 1) 4 percent aq. NaOH, 2) 6 N HCl / 1) MeOH, reflux, 2 h, 2) r.t., 1 h View Scheme
参考文献
Keinan, Ehud; Sinha, Subhash C.; Sinha-Bagchi, Anjana
Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3631 - 3636
