3-氯-4-(3-氟苄氧基)苯胺合成路线 （共 18 条）
参考文献
Lackey, Karen Elizabeth; Spector, Neil; Wood lll, Edgar Raymond; Xia, Wenle
Patent: US2004/53946 A1, 2004 ;
反应条件
iron; acetic acid in ethyl acetate T=20°C;
参考文献
BAYER HEALTHCARE AG
Patent: US2010/298297 A1, 2010 ;
Location in patent: Page/Page column 14 ;
反应条件
1: K2CO3 / acetonitrile 2: H2 / Pt/C / ethanol; tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
反应条件
1: K2CO3 / acetonitrile 2: H2 / Pt/C / ethanol; tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
反应条件
1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere 2: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 2 h View Scheme
参考文献
WO2011/2523 A1, ;
WO 2011/002523 A1
反应条件
1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere 2: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 2 h View Scheme
参考文献
WO2011/2523 A1, ;
WO 2011/002523 A1
反应条件
1: acetic acid / toluene / 2 h / Reflux 2: acetic acid / xylene / 10 h / Reflux 3: triethylamine / palladium 10 on activated carbon / ethylene glycol dimethyl ether; methanol / 15 h / 45 - 50 °C / Inert atmosphere 4: triethylamine / methanol / 12 h / Reflux 5: sodium tetrahydroborate / tetrahydrofuran; methanol / 4 h / 10 - 15 °C 6: methanol / 3 h / 25 - 65 °C View Scheme
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: acetic acid; iron / methanol / 2.5 h / 85 °C 3: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: acetic acid; iron / methanol / 2.5 h / 85 °C 3: triethylamine / tetrahydrofuran / 3 h / 20 °C / Cooling with ice 4: water; tetrahydrofuran; methanol View Scheme
参考文献
Guo, Jianhui; Jiang, Yong
Patent: US2012/4249 A1, 2012 ;
反应条件
1: propan-2-ol / 70 °C 2: Pd(OAc)2; PPh3; Et3N / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691
