3-乙氧基-联苯-4-羧酸合成路线 （共 3 条）
反应条件
1: With sodium carbonate; palladium 10 on activated carbon in water; isopropyl alcohol T=80°C; 24 h; 2: pH=2; Acidic conditions;
参考文献
AMGEN INC.
Patent: WO2007/106469 A2, 2007 ;
Location in patent: Page/Page column 86 ;
反应条件
1: 1.) n-BuLi, 2.) ZnCl2, 3.) (Ph3P)2PdCl2, (i-Bu)2AlH 2: aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Klein, Scott I.; Czekaj, Mark; Gardner, Charles J.; Guertin, Kevin R.; Cheney, Daniel L.; Spada, Alfred P.; Bolton, Scott A.; Brown, Karen; Colussi, Dennis; Heran, Christopher L.; Morgan, Suzanne R.; Leadley, Robert J.; Dunwiddie, Christopher T.; Perrone, Mark H.; Chu, Valeria
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 437 - 450
反应条件
1: 1.) n-BuLi, 2.) ZnCl2, 3.) (Ph3P)2PdCl2, (i-Bu)2AlH 2: aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Klein, Scott I.; Czekaj, Mark; Gardner, Charles J.; Guertin, Kevin R.; Cheney, Daniel L.; Spada, Alfred P.; Bolton, Scott A.; Brown, Karen; Colussi, Dennis; Heran, Christopher L.; Morgan, Suzanne R.; Leadley, Robert J.; Dunwiddie, Christopher T.; Perrone, Mark H.; Chu, Valeria
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 437 - 450
