Pearlman's catalist; hydrogen in tetrahydrofuran; ethanol 12 h;

1: With potassium carbonate in dimethyl sulfoxide Koenigs-Knorr reaction; 2: With sodium methylate in methanol T=20°C; 0.333333 h;

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 2.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 2.2: ion-exchange resin / 0.5 h 3.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme

1.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 1.2: ion-exchange resin / 0.5 h 2.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme

1.1: 0.17 h / 180 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: water; acetic acid / 2 h / Reflux 4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere 5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 6.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 6.2: ion-exchange resin / 0.5 h 7.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 2.1: water; acetic acid / 2 h / Reflux 3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere 4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 5.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 5.2: ion-exchange resin / 0.5 h 6.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 3.2: ion-exchange resin / 0.5 h 4.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme

1.1: water; acetic acid / 2 h / Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 4.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 4.2: ion-exchange resin / 0.5 h 5.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / Inert atmosphere 2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 3.1: sodium methylate / tetrahydrofuran; methanol / 20 °C 3.2: ion-exchange resin / 0.5 h 4.1: Pearlman's catalist; hydrogen / tetrahydrofuran; ethanol / 12 h View Scheme

Populus deltoids Marsh PGT-3 T=37°C; pH=7.5; 0.5 h; aq. phosphate bufferEnzymatic reaction; Kinetics; regioselective reaction;