3-乙基-4-甲酰基苯甲腈合成路线 （共 4 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=220°C; 0.0833333 h; Inert atmosphereMicrowave irradiation;
参考文献
ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
Location in patent: Page/Page column 52 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=200°C; 0.25 h; Microwave irradiation;
参考文献
ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
Location in patent: Page/Page column 52 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 1 h 2.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 200 °C / |Microwave irradiation View Scheme
参考文献
ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
反应条件
sodium tetrahydroborate in methanol T=0 - 20°C; Reduction; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 6 p. 1203 - 1214
