4-氨基-2-甲氧基吡啶合成路线 （共 18 条）
反应条件
1: NaNO2, 48percent fluoroboric acid / 1) 0 deg, 45 min, 2) 0 deg C - RT, 30 min, 30 - 35 deg C, 30 min 2: 69 percent / iodotrimethylsilane / CH2Cl2 / 1.) RT, 4 h, 2.) 40 deg C, 1 h, RT, overnight View Scheme
参考文献
Leznoff; Svirskaya; Yedidia
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 145 - 147
反应条件
tetrafluoroboric acid; sodium nitrite 1) 0 deg, 45 min, 2) 0 deg C - RT, 30 min, 30 - 35 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Leznoff; Svirskaya; Yedidia
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 1 p. 145 - 147
反应条件
water Diazotization;
参考文献
Talik; Plazek
Roczniki Chemii, 1959 , vol. 33, p. 1343,1345
Chem.Abstr., 1960 , p. 13123
反应条件
N-bromosuccinmide in acetic acid T=10 - 35°C; 3 h;
参考文献
EISAI RandD MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki
Patent: US2013/143907 A1, 2013 ;
Location in patent: Paragraph 0418; 0419 ;
反应条件
copper(II) sulfate; sodium bromide; sodium nitrite; sulfuric acid T=0°C;
参考文献
Fraley, Mark E; Rubino, Robert S; Hoffman, William F; Hambaugh, Scott R; Arrington, Kenneth L; Hungate, Randall W; Bilodeau, Mark T; Tebben, Andrew J; Rutledge, Ruth Z; Kendall, Richard L; McFall, Rosemary C; Huckle, William R; Coll, Kathleen E; Thomas, Kenneth A
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 24 p. 3537 - 3541
反应条件
1: H2O / Diazotization 2: aqueous HCl View Scheme
参考文献
Talik; Plazek
Roczniki Chemii, 1959 , vol. 33, p. 1343,1345
Chem.Abstr., 1960 , p. 13123
反应条件
N-bromosuccinmide in acetonitrile T=10 - 20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/113565 A1, 2007 ;
Location in patent: Page/Page column 98 ;
WO 2007/113565 A1
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile T=20°C; 18 h;
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
Location in patent: Page/Page column 135-136 ;
WO 2012/088469 A1
