5-氨基-1-苯基-1H-1,2,3-噻唑-4-羧酸乙酯合成路线 （共 8 条）
参考文献
Beecham Group Limited
Patent: US4223032 A1, 1980 ;
参考文献
Al-Azmi, Amal; Kalarikkal, Anita K.
Tetrahedron, 2013 , vol. 69, # 52 p. 11122 - 11129
反应条件
1: 70 percent / NaOEt / ethanol / 3 h / Ambient temperature 2: 75 percent / dioxane / 4 h / Ambient temperature 3: 1) NaOEt, 2) PhSO2N3 / 1) EtOH, 5 min, 2) 1 h, r.t. View Scheme
参考文献
Dankova, E. F.; Bakulev, V. A.; Krut'ko, D. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 6 p. 607 - 613
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , vol. 27, # 6 p. 775 - 782
反应条件
1: 75 percent / dioxane / 4 h / Ambient temperature 2: 1) NaOEt, 2) PhSO2N3 / 1) EtOH, 5 min, 2) 1 h, r.t. View Scheme
参考文献
Dankova, E. F.; Bakulev, V. A.; Krut'ko, D. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 6 p. 607 - 613
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , vol. 27, # 6 p. 775 - 782
反应条件
benzenesulphonyl azide; sodium ethanolate 1) EtOH, 5 min, 2) 1 h, r.t.; Yield given. Multistep reaction;
参考文献
Dankova, E. F.; Bakulev, V. A.; Krut'ko, D. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 6 p. 607 - 613
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , vol. 27, # 6 p. 775 - 782
反应条件
1: ethanol / 3 h / 20 °C 2: |Reflux View Scheme
参考文献
Al-Azmi, Amal; Kalarikkal, Anita K.
Tetrahedron, 2013 , vol. 69, # 52 p. 11122 - 11129
反应条件
hydrazine hydrate in ethanol T=80°C; Dimroth rearrangement; Reflux;
参考文献
Cao, Zi-Ping; Quan, Bin; Dong, Heng-Shan
Journal of the Chinese Chemical Society, 2008 , vol. 55, # 4 p. 761 - 767
反应条件
sodium hydroxide in ethanol
2 h; Heating;
参考文献
Chen, Mindong; Zheng, Youfei; Fan, Shuxian; Gao, Guizhi; Yang, Lei; Tian, Lu; Du, Yiping; Tang, Feng; Hua, Weiyi
Synthetic Communications, 2006 , vol. 36, # 8 p. 1063 - 1070
