2-(苄氧基)-1-溴-4-氟苯合成路线 (共 5 条)
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION; SHIONOGI and CO. LTD; KAWASUJI, Takashi
Patent: WO2007/19098 A2, 2007 ;
Location in patent: Page/Page column 42-43 ;
反应条件
potassium carbonate in acetone
参考文献
US6218431 B1, ;
US 6218431 B1
反应条件
1: benzyl alcohol With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 2,4-difluoro-1-bromobenzene in tetrahydrofuran T=20°C; 17 h; Further stages. Title compound not separated from byproducts.;
参考文献
Tetrahedron Letters, , vol. 49, # 31 p. 4588 - 4590
反应条件
magnesium in tetrahydrofuran T=65°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; SHIONOGI and CO. LTD; KAWASUJI, Takashi
Patent: WO2007/19098 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
1: methanol With potassium tert-butylate in N,N-dimethyl-formamide T=0°C; 0.166667 h; prs; 2: 2-benzyloxy-1-bromo-4-fluorobenzene in N,N-dimethyl-formamide T=80°C; 20 h; Further stages.;
参考文献
Dirr, Ronan; Anthaume, Cyril; Desaubry, Laurent
Tetrahedron Letters, 2008 , vol. 49, # 31 p. 4588 - 4590